Selected Publications

 

1.        Unger, R., Harel, D., Wherland, S., and Sussman, J.L. 1989. A 3D building blocks approach to analyzing and predicting structure of proteins. Proteins, 5: 355-373. (Medline abstract, Building blocks figure )

2.        Moult, J. and Unger, R. 1991. An analysis of protein folding pathways. Biochemistry, 30: 3816-3824. (Medline abstract)

3.        Unger, R. and Moult, J. 1993. Genetic algorithms for protein folding simulations. J. Molec. Biol. 231: 75-81. (pdf format).

4.        Unger, R. and Moult, J. 1993. Finding the lowest free energy conformation of a protein is a NP-Hard problem: Proof and implications. Bul. Math. Biol. 55: 1183-1198. (Medline abstract ).

5.        Kandel, D., Matias, Y., Unger, R.,Winkler, P. 1996. Shuffling Biological Sequences. Discrete Appl. Math. 71: 171-186.  (pdf format)

6.        Unger, R. and Moult, J. 1996. Local interactions dominate folding in a simple protein model. J. Molec. Biol. 259: 988-994. (pdf format).

7.        Bucci, E., Razynska, A., Kwansa, H., Gryczynski, Z., Collins, J.H., Fronticelli, C., Unger, R., Braxenthaler, M., Moult, J., Ji, X. and Gilliland, G. 1996. Positive and negative cooperativities at subsequent steps of oxygenation regulate the allosteric behavior of multistate sebacyl-hemoglobin. Biochemistry 35: 3418-3425. (pdf format).

8.        Braxenthaler, M., Unger, R., Auerbach, D., Given, G. and Moult, J. 1997. Chaos in protein folding dynamics. Proteins, 29: 417-425. (pdf format).

9.        Yadgari, J., Amir, A., Unger, R., 1998. Genetic algorithms for protein threading. Proc. Int. Con. on Intelligent Systems for Molecular Biology, ISMB 98:193-202, AAAI Press. (Medline abstract).

10.     Kaffe-Abramovich, T. and Unger, R., 1998. A simple model for evolution of protein towards the global minimum of free energy. Folding & Design, 3: 389-399. (pdf format).

11.     Uliel, S., Fliess, A., Amir, A. and Unger, R. 1999. A Simple Algorithm for Detecting Circular Permutations in Proteins. Bioinformatics, 15: 930-936. (pdf format).

12.     Albeck, S., Unger, R. and Schreiber, G. 2000. Evaluation of Direct and Cooperative Contributions towards the Strength of Buried Hydrogen Bonds and Salt Bridges. Journal of Molecular Biology, 298: 503-520. (pdf format).

13.     Uliel, S, Fliess, A. and Unger, R. 2001. Naturally Occurring Circular Permutations in Proteins. Protein Engineering 14: 533-542. (pdf format).

14.     Fliess, A., Motro, B. and Unger, R. 2002. Swaps in protein sequences. Proteins, 48:377-387. (pdf format).

15.     Liu, Q., Liang, X., Uliel, S., Unger, R., Ullu, E. and Michaeli, S. 2002. RNA interference of signal peptide-binding Protein SRP54 elicits deleterious effects and protein sorting defects in Trypanosomes. JBC, 277:47348-47357. (pdf format).

16.     Unger, R., Uliel, S. and Havlin, S. 2003. Scaling law in sizes of protein sequence families: From super-families to orphan genes. Proteins, 51:569-576. (pdf format).

17.     Horesh, Y., Amir, A., Michaeli, S. and Unger, R. 2003. A rapid method for detection of putative RNAi target genes in genomic data. Bioinformatics, 19:ii73-ii80. (pdf format).

18.     Liu, Q., Liang, X., Uliel, S., Belahcen, M., Unger, R. and Michaeli, S. 2004. Identification and functional characterization of lsm proteins in trypanosome brucei. The Journal of Biological Chemistry, 279:18210-18219. (pdf format).

19.     Liang XH, Uliel S, Hury A, Barth S, Doniger T, Unger R, Michaeli S. 2005. A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification. RNA.  May;11(5):619-45. (pdf format)

20.     Unger R, Moult J. 2006. Towards computing with proteins. Proteins. 2006 Apr 1;63(1):53-64. (pdf format)

21.     Horesh Y, Mehr R, Unger R. 2006. Designing an A* algorithm for calculating edit distance between rooted-unordered trees. J Comput Biol. Jul-Aug;13(6):1165-76. (pdf format)

22.     Jacob, E. and Unger, R. 2007. A tale of two tails: why are terminal residues of proteins exposed? Bioinformatics, 23:e225-e230. (pdf format).

23.     Horesh Y, Doniger T, Michaeli S, Unger R. 2007. RNAspa: a shortest path approach for comparative prediction of the secondary structure of ncRNA molecules. BMC Bioinformatics. Oct 1;8:366. (pdf format)

24.     Noivirt-Brik O, Unger R, Horovitz A. 2007. Low folding propensity and high translation efficiency distinguish in vivo substrates of GroEL from other Escherichia coli proteins. Bioinformatics. Dec 15;23(24):3276-9. (pdf format)

25.     Ashkenazy H, Unger R, Kliger Y. 2008 Optimal data collection for correlated mutation analysis. Proteins. Jul 24. (pdf format)

26.     Barak M, Zuckerman NS, Edelman H, Unger R, Mehr R. 2008. IgTree: creating Immunoglobulin variable region gene lineage trees. J Immunol Methods. Sep 30;338(1-2):67-74. (pdf format)

27.     Myslyuk I, Doniger T, Horesh Y, Hury A, Hoffer R, Ziporen Y, Michaeli S, Unger R. 2008. Psiscan: a computational approach to identify H/ACA-like and AGA-like non-coding RNA in trypanosomatid genomes. BMC Bioinformatics. Nov 5;9(1):471. (pdf format)

28.     Noivirt-Brik O, Unger R, Horovitz A. Analysing the origin of long-range interactions in proteins using lattice models. BMC Struct Biol. 2009 Jan 29;9:4.  (pdf format)

29.     Doniger T, Michaeli S, Unger R. Families of H/ACA ncRNA molecules in trypanosomatids. RNA Biol. 2009 Sep-Oct;6(4):370-4.  (pdf format)

30.      Noivirt-Brik O, Horovitz A, Unger R. Trade-off between positive and negative design of protein stability: from lattice models to real proteins. PLoS Comput Biol. 2009 Dec;5(12):e1000592. (pdf format)

31.     Yomtovian I, Teerakulkittipong N, Lee B, Moult J, Unger R. Composition bias and the origin of ORFan genes. Bioinformatics. 2010 Apr 15;26(8):996-9. (pdf format)

32.     Yehoshua R, Avigal M,Unger R. Analysis of the effects of lifetime learning on population fitness using vose model. Proceedings of the 12th annual conference on Genetic and evolutionary computation, GECCO 2010. (pdf format)

33.     Lebenthal I, Unger R. Computational evidence for functionality of noncoding mouse transcripts. Genomics. 2010 Jul;96(1):10-6. Epub 2010 Mar 25. (pdf format)

34.     Malnick SD, Bar-Ilan A, Goland S, Somin M, Doniger T, Basevitz A, Unger R. Perimyocarditis following streptococcal group A infection: from clinical cases to bioinformatics analysis. Eur J Intern Med. 2010 Aug;21(4):354-6. (pdf format)

35.     Doniger T, Katz R, Wachtel C, Michaeli S, Unger R. A comparative genome-wide study of ncRNAs in trypanosomatids. BMC Genomics. 2010 Nov 4;11:615. (pdf format)

36.     Ashkenazy H, Unger R, Kliger Y. Hidden conformations in protein structures. Bioinformatics. 2011 May 17. (pdf format)